The DEAD-box RNA helicase RhlB is required for efficient RNA processing at low temperature in Caulobacter.

ABSTRACT:

Importance

One of the most important control points in gene regulation is RNA stability, which determines the half-life of a transcript from its transcription until its degradation. Bacteria have evolved a sophisticated multi-enzymatic complex, the RNA degradosome, which is dedicated mostly to RNA turnover. The combined activity of RNase E and the other RNA degradosome enzymes provides an efficient pipeline for the complete degradation of RNAs. The DEAD-box RNA helicases are very often found in RNA degradosomes from phylogenetically distant bacteria, confirming their importance in unwinding structured RNA for subsequent degradation. This work showed that the absence of the RNA helicase RhlB in the free-living Alphaproteobacterium Caulobacter crescentus causes important chang

SUBMITTER: de Araujo HL 

PROVIDER: S-EPMC10715135 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature