Phosphorus starvation response and PhoB-independent utilization of organic phosphate sources by Salmonella enterica.

ABSTRACT:

Importance

Phosphorus (P) is the fifth most abundant element in living cells. This element is acquired mainly as inorganic phosphate (Pi, PO₄ ^3-). In enteric bacteria, P starvation activates a two-component signal transduction system which is composed of the membrane sensor protein PhoR and its cognate transcription regulator PhoB. PhoB, in turn, promotes the transcription of genes that help maintain Pi homeostasis. Here, we characterize the P starvation response of the bacterium Salmonella enterica. We determine the PhoB-dependent and independent transcriptional changes promoted by P starvation and identify proteins enabling the utilization of a range of organic substrates as sole P sources. We show that transcription and activity of a subset of these

SUBMITTER: Bruna RE 

PROVIDER: S-EPMC10715179 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature