Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station.

ABSTRACT:

Importance

The International Space Station (ISS) is a unique, hermetically sealed environment, subject to environmental pressures not encountered on Earth, including microgravity and radiation (cosmic ionising/UV). While bacteria's adaptability during spaceflight remains elusive, recent research suggests that it may be species and even clone-specific. Considering the documented spaceflight-induced suppression of the human immune system, a deper understanding of the genomics of potential human pathogens in space could shed light on species and lineages of medical astromicrobiological significance. In this study, we used hybrid assembly methods and comparative genomics to deliver a comprehensive genomic characterization of 10 Klebsiella isolates retrieved from the ISS. Our ana

SUBMITTER: Miliotis G 

PROVIDER: S-EPMC10715203 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature