Airway microbiota correlated with pulmonary exacerbation in primary ciliary dyskinesia patients.

ABSTRACT:

Importance

PCD is a rare disease characterized by productive cough, rhinitis, and recurrent infections of the upper and lower airways. Because the diagnosis of PCD is often delayed, patients receive more antibiotics, experience a heavier financial burden, and have a worse prognosis; thus, it is very important to identify the pathogeny and use the correct antibiotic. In this large single-center study of PCD microbiota, we identified an outline of the bacterial microbes from the respiratory tract; furthermore, we found that the microbiota diversity in pediatric sputum was richer than that in pediatric BALF through sequencing, indicating a heterogeneous community structure. The microbiota diversity and richness were lower during pulmonary exacerbation than during pulmonary stabilizati

SUBMITTER: Zhou W 

PROVIDER: S-EPMC10715216 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature