Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization.

ABSTRACT:

Importance

The important enteropathogen Salmonella can cause lethal systemic infection via survival and replication in host macrophages. Lactate represents an abundant intracellular metabolite during bacterial infection, which can also induce macrophage M2 polarization. In this study, we found that macrophage-derived lactate promotes the intracellular replication and systemic infection of Salmonella. During Salmonella infection, lactate via the Salmonella type III secretion system effector SteE promotes macrophage M2 polarization, and the induction of macrophage M2 polarization by lactate is responsible for lactate-mediated Salmonella growth promotion. This study highlights the complex interactions between Salmonella and macro

SUBMITTER: Wang X 

PROVIDER: S-EPMC10715217 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature