Municipal wastewater monitoring revealed the predominance of bla _GES genes with diverse variants among carbapenemase-producing organisms: high occurrence and persistence of Aeromonas caviae harboring the new bla _GES variant bla _GES-48.

ABSTRACT:

Importance

The emergence and spread of carbapenemase-producing organisms (CPOs) represent a global health threat because they are associated with limited treatment options and poor clinical outcomes. Wastewater is considered a hotspot for the evolution and dissemination of antimicrobial resistance. Thus, analyses of municipal wastewater are critical for understanding the circulation of these CPOs and carbapenemase genes in local communities, which remains scarcely known in Japan. This study resulted in several key observations: (i) the vast majority of bla _GES genes, including six new bla _GES variants, and less frequent bla _IMP genes were carbapenemase genes encountered exclusively in wastewater influent; (ii) the most dominant

SUBMITTER: Tanabe M 

PROVIDER: S-EPMC10715227 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature