Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.

ABSTRACT:

Objective

Both alanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are closely related to glucose homeostasis in the body, and the main objective of this study was to investigate the association between ALT to HDL-C ratio (ALT/HDL-C ratio) and the risk of diabetes in a Chinese population.

Methods

The current study included 116,251 participants who underwent a healthy physical examination, and the study endpoint was defined as a diagnosis of new-onset diabetes. Multivariate Cox regression models and receiver operator characteristic curves were used to assess the association of the ALT/HDL-C ratio with diabetes onset.

Results

During the average observation period of 3.10 years, a total of 2,674 (2.3%) participants were diagnosed with new-onse

SUBMITTER: He S 

PROVIDER: S-EPMC10715265 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature