Association between the neutrophil-to-lymphocyte ratio and cognitive impairment: a meta-analysis of observational studies.

ABSTRACT:

Background

Systemic inflammation is one of the underlying mechanisms of cognitive impairment. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a systemic inflammation indicator. This meta-analysis aimed to evaluate the association between high NLR and cognitive impairment (CI) risk.

Method

A comprehensive systematic search was conducted to identify eligible studies published until May 30, 2023. The reference group comprised patients with the lowest NLR level, whereas the exposure group comprised those with the highest NLR level. The main outcome was to examine the relationship between NLR and CI risk. The secondary outcome included the association between patient characteristics or comorbidities and CI risk.

Results

This meta-analysis included 11 studies publis

SUBMITTER: Hung KC 

PROVIDER: S-EPMC10715314 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature