Pharmacokinetics and Proposed Dosing of Levetiracetam in Children With Obesity.

ABSTRACT:

Objective

Characterize levetiracetam pharmacokinetics (PK) in children with obesity to inform dosing.

Methods

Children 2 to <21 years old receiving standard of care oral levetiracetam across two opportunistic studies provided blood samples. Levetiracetam plasma PK data were analyzed with a nonlinear mixed-effects modeling approach. Indirect measures for body size and covariates were tested for model inclusion. Individual empirical Bayesian estimates using the final model parameters were compared by obesity status. Monte Carlo simulation using total body weight was performed in children with normal estimated glomerular filtration rate to identify dosing for children with obesity that resulted in comparable exposures to normal weight adults and children after receiving label d

SUBMITTER: Zimmerman KO 

PROVIDER: S-EPMC10715382 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature