Gut microbiota and immune mediation: a Mendelian randomization study on granulomatosis with polyangiitis.

ABSTRACT:

Background

The gut microbiota plays a pivotal role in influencing various health outcomes, including immune-mediated conditions. Granulomatosis with Polyangiitis (GPA) is one such condition, and its potential associations with gut microbiota remain underexplored.

Method

Using a two-sample Mendelian randomization approach, we investigated the causal links between gut microbiota and GPA. We sourced our data from multiple cohorts and consortiums, including the MiBioGen consortium. Our study design incorporated both direct associations and mediation effects of immune traits on the relationship between gut microbiota and GPA.

Results

Our analysis revealed significant associations between 1 phylum, 1 family 9 genus microbiota taxa and GPA. Furthermore, we identified several

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10715420 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature