Engineered living materials for the conversion of a low-cost food-grade precursor to a high-value flavonoid.

ABSTRACT: Microbial biofactories allow the upscaled production of high-value compounds in biotechnological processes. This is particularly advantageous for compounds like flavonoids that promote better health through their antioxidant, anti-bacterial, anti-cancer and other beneficial effects but are produced in small quantities in their natural plant-based hosts. Bacteria like E. coli have been genetically modified with enzyme cascades to produce flavonoids like naringenin and pinocembrin from coumaric or cinnamic acid. Despite advancements in yield optimization, the production of these compounds still involves high costs associated with their biosynthesis, purification, storage and transport. An alternative production strategy could involve the direct delivery of the microbial biofactories t

SUBMITTER: Riedel F 

PROVIDER: S-EPMC10715425 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature