Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse.

ABSTRACT:

Introduction

Patients with high-risk, triple negative breast cancer (TNBC) often receive neoadjuvant chemotherapy (NAC) alone or with immunotherapy. Various single-cell and spatially resolved techniques have demonstrated heterogeneity in the phenotype and distribution of macrophages and T cells in this form of breast cancer. Furthermore, recent studies in mice have implicated immune cells in perivascular (PV) areas of tumors in the regulation of metastasis and anti-tumor immunity. However, little is known of how the latter change during NAC in human TNBC or their impact on subsequent relapse, or the likely efficacy of immunotherapy given with or after NAC.

Methods

We have used multiplex immunofluorescence and AI-based image analysis to compare the immune landscape in untreat

SUBMITTER: Moamin MR 

PROVIDER: S-EPMC10715438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature