FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.

ABSTRACT:

Objective

Immunotherapy for the treatment of pancreatic ductal adenocarcinoma (PDAC) has shown limited efficacy. Poor CD8 T-cell infiltration, low neoantigen load and a highly immunosuppressive tumour microenvironment contribute to this lack of response. Here, we aimed to further investigate the immunoregulatory function of focal adhesion kinase (FAK) in PDAC, with specific emphasis on regulation of the type-II interferon response that is critical in promoting T-cell tumour recognition and effective immunosurveillance.

Design

We combined CRISPR, proteogenomics and transcriptomics with mechanistic experiments using a Kras^G12Dp53^R172H mouse model of pancreatic cancer and validated findings using proteomic analysis of human patient-derived PDAC cell lines

SUBMITTER: Canel M 

PROVIDER: S-EPMC10715489 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature