Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study.

ABSTRACT:

Background

Vaccines have reduced severe disease and death from Coronavirus Disease 2019 (COVID-19). However, with evidence of waning efficacy coupled with continued evolution of the virus, health programmes need to evaluate the requirement for regular booster doses, considering their impact and cost-effectiveness in the face of ongoing transmission and substantial infection-induced immunity.

Methods and findings

We developed a combined immunological-transmission model parameterised with data on transmissibility, severity, and vaccine effectiveness. We simulated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission and vaccine rollout in characteristic global settings with different population age-structures, contact patterns, health system capacities, pri

SUBMITTER: Hogan AB 

PROVIDER: S-EPMC10715640 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature