Cystatin F (<i>Cst7</i>) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.

ABSTRACT: Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's disease (AD) models and human AD brain, and that the emergence of this state is emphasised in females. Cst7 (encoding cystatin F) is among the most highly upregulated genes in these microglia. However, despite such striking and robust upregulation, the function of Cst7 in neurodegenerative disease is not understood. Here, we crossed Cst7^-/- mice with the App^NL-G-F mouse to test the role of Cst7 in a model of amyloid-driven AD. Surprisingly, we found that Cst7 plays a sexually dimorph

SUBMITTER: Daniels MJD 

PROVIDER: S-EPMC10715728 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature