Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis.

ABSTRACT:

Background

Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. Ischemia-reperfusion injury during transplantation triggers a local thromboinflammatory response. We aimed to evaluate local graft inflammation and its potential association with early graft thrombosis.

Methods

In this observational study, we monitored 67 pancreas-transplanted patients using microdialysis catheters placed on the pancreatic surface during the first postoperative week. We analyzed 6 cytokines, interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-8, interferon gamma-induced protein 10 (IP-10), macrophage inflammatory protein 1β (MIP-1β), IL-10, a

SUBMITTER: Rydenfelt K 

PROVIDER: S-EPMC10715763 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature