Dementia Risk of Direct Oral Anticoagulants Versus Warfarin for Atrial Fibrillation: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Direct-acting oral anticoagulants (DOACs) have demonstrated superior efficacy in preventing stroke and death compared with warfarin in patients with atrial fibrillation (AF), but their influence on dementia risk remains unclear.

Objectives

The purpose of this study was to evaluate the relative risks of dementia in DOAC vs warfarin in patients with AF.

Methods

An electronic literature search was conducted to retrieve studies reporting comparisons of dementia incidence between patients treated with DOACs and warfarin for AF. HRs and 95% CI were pooled in a random-effects meta-analysis. Meta-regression was performed to identify prognostic baseline variables. Network meta-analysis was performed to determine dementia risk between individual DOACs and warfarin.

SUBMITTER: Fong KY 

PROVIDER: S-EPMC10715893 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature