LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.

ABSTRACT: Adult planarians can regenerate the gut, eyes and even a functional brain. Proper identity and patterning of the newly formed structures require signals that guide and commit their adult stem cells. During embryogenesis, LIM-homeodomain (LIM-HD) transcription factors act in a combinatorial 'LIM code' to control cell fate determination and differentiation. However, our understanding about the role these genes play during regeneration and homeostasis is limited. Here, we report the full repertoire of LIM-HD genes in Schmidtea mediterranea. We found that lim homeobox (lhx) genes appear expressed in complementary patterns along the cephalic ganglia and digestive system of the planarian, with some of them being co-expressed in the same cell types. We have identified that

SUBMITTER: Molina MD 

PROVIDER: S-EPMC10715919 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature