Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.

ABSTRACT: Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylglyceride (TAG) content. We investigated if Plin2 is important for hepatic LD storage in fasted or high-fat diet-induced obese Plin2^+/+ and Plin2^-/- mice. Plin2^-/- mice had comparable body weights, metabolic phenotype, glucose tolerance, and circulating TAG and total cholesterol levels compared with Plin2^+/+ mice, regardless of the dietary regime. Both fasted and high-fat fed Plin2^-/- mice stored reduced levels of hepatic TAG compared with Plin2^+/+ mice. Fasted Plin2^-/- mice stored fewer but larger hepatic LDs compared with Plin2^+/+ mice. Detailed hepatic lipid analysis showed subst

SUBMITTER: Doncheva AI 

PROVIDER: S-EPMC10716011 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature