Changes in miRNA expression in the lungs of pigs supplemented with different levels and forms of vitamin D.

ABSTRACT:

Background

Vitamin D is an immunomodulator, and its effects have been linked to many diseases, including the pathogenesis of cancer. However, the effect of vitamin D supplementation on the regulation of gene expression of the lungs is not fully understood. This study aims to determine the effect of the increased dose of cholecalciferol and a combination of cholecalciferol + calcidiol, as well as the replacement of cholecalciferol with calcidiol, on the miRNA profile of healthy swine lungs.

Methods and results

The swine were long-term (88 days) supplemented with a standard dose (2000IU/kg) of cholecalciferol and calcidiol, the increased dose (3000 IU/kg) of cholecalciferol, and the cholecalciferol + calcidiol combination: grower: 3000 IU/Kg of vitamin D (67% of cholecalcifero

SUBMITTER: Wierzbicka A 

PROVIDER: S-EPMC10716066 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature