Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture.

ABSTRACT: From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitudinal diffusion MRI cohort of 604 participants, we map the developmental trajectory of the white matter connectome from global to regional levels and identify that most brain network properties followed a linear developmental trajectory. Importantly, connectome-transcriptomic analysis reveals that the spatial development pattern of white matter connectome is potentially regulated by the transcriptomic architecture, with positively correlated genes involve in ion transport- and development-related pathways expressed in excitatory and inhibitory neurons, and negatively correlated genes

SUBMITTER: Feng G 

PROVIDER: S-EPMC10716168 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature