Mass cytometric analysis unveils a disease-specific immune cell network in the bone marrow in acquired aplastic anemia.

ABSTRACT: Idiopathic acquired aplastic anemia (AA) is considered an immune-mediated syndrome of bone marrow failure since approximately 70% of patients respond to immunosuppressive therapy (IST) consisting of a course of anti-thymocyte globulin (ATG) followed by long-term use of ciclosporin. However, the immune response that underlies the pathogenesis of AA remains poorly understood. In this study, we applied high-dimensional mass cytometry on bone marrow aspirates of AA patients pre-ATG, AA patients post-ATG and healthy donors to decipher which immune cells may be implicated in the pathogenesis of AA. We show that the bone marrow of AA patients features an immune cell composition distinct from healthy donors, with significant differences in the myeloid, B-cell, CD4⁺ and CD8⁺ T

SUBMITTER: Pool ES 

PROVIDER: S-EPMC10716190 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature