In silico studies on cytotoxicity and antitumoral activity of acetogenins from Annona muricata L.

ABSTRACT: As life expectancy increases, the number of people affected by cancer is increasing. The available drugs still cause several adverse reactions, and it is important to look for less toxic drugs that act on resistant cancers. The present study evaluated the antitumor potential of acetogenins. Through a literature review, 44 acetogenins isolated from Annona muricata were selected and subjected to in silico studies to predict the physicochemical properties, pharmacokinetics (Preadmet and Admet lab), toxicity (Preadmet and Protox II) and molecular docking in caspase 3 (DockThor). For muricatacin, a literature review was carried out for antitumor activity and cytotoxicity. Only muricatacin met all physicochemical criteria, while all compounds showed high cutaneous and intestinal ab

SUBMITTER: Fallon Adido HE 

PROVIDER: S-EPMC10716197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature