Enhancing decellularized vascular scaffolds with PVDF and PCL reinforcement: a fused deposition modeling approach.

ABSTRACT:

Background

Decellularized xenogenic scaffolds represent a promising substrate for tissue-engineered vascular prostheses, particularly those with smaller diameters (<6 mm). Despite their benefits, a notable limitation presents itself during decellularization, namely, the diminished mechanical strength that introduces the risk of aneurysmal dilations in the early post-implantation period. This study introduces a strategy for modification the mechanical properties of these biological scaffolds through the forming of an external polymeric reinforcement via thermal extrusion.

Methods

The study utilized scaffolds fabricated from bovine internal mammary arteries through decellularization and preservation. The scaffolds were divided into subgroups and reinforced with polymeric helic

SUBMITTER: Klyshnikov KY 

PROVIDER: S-EPMC10716200 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature