Global phylogenomic diversity of Brucella abortus: spread of a dominant lineage.

ABSTRACT: Brucella abortus is a globally important zoonotic pathogen largely found in cattle hosts and is typically transmitted to humans through contaminated dairy products or contact with diseased animals. Despite the long, shared history of cattle and humans, little is known about how trade in cattle has spread this pathogen throughout the world. Whole genome sequencing provides unparalleled resolution to investigate the global evolutionary history of a bacterium such as B. abortus by providing phylogenetic resolution that has been unobtainable using other methods. We report on large-scale genome sequencing and analysis of B. abortus collected globally from cattle and 16 other hosts from 52 countries. We used single nucleotide polymorphisms (SNPs) to identify genetic variatio

SUBMITTER: Janke NR 

PROVIDER: S-EPMC10716283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature