Semaphorin 7A is protective during inflammatory peritonitis through integrin receptor signaling.

ABSTRACT:

Introduction

The study explores the role of endothelial Semaphorin 7A (SEMA7A) in inflammatory processes. SEMA7A is known for enhancing inflammation during tissue hypoxia and exhibiting anti-inflammatory properties in the intestinal system during colitis. This research extends the understanding of SEMA7A's function by examining its role in inflammatory peritonitis and intestinal inflammation.

Methods

The research involved inducing peritonitis in SEMA7A knockout (SEMA7A^-/-) and wild-type (WT) animals through Zymosan A (ZyA) injection. The inflammatory response was assessed by measuring cell count and cytokine release. In parallel, the study investigated the expression of SEMA7A in intestinal epithelial cells under inflammatory stimuli and its impact on inter

SUBMITTER: Korner A 

PROVIDER: S-EPMC10716335 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature