Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice.

ABSTRACT: The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, but the downstream target regions participating in this control process remain unknown. Here, using circuit-specific fiber photometry and single-neuron electrophysiology together with electroencephalogram, electromyogram and behavioral recordings, we find that approximately half of SuM neurons that project to the medial septum (MS) are wake-active. Optogenetic stimulation of axonal terminals of SuM-MS projection induces a rapid and reliable transition to wakefulness from non-rapid-eye movement or rapid-eye movement sleep, and chemogenetic activation of SuM^MS projecting neurons significantly increases wakefulness time and prolongs latency to sleep. Consistently, chemogenetically inhibi

SUBMITTER: Liang M 

PROVIDER: S-EPMC10716381 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature