Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients.

ABSTRACT: Inflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relat

SUBMITTER: Martinez-Banaclocha H 

PROVIDER: S-EPMC10716420 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature