Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review.

ABSTRACT: The neurological complications of coronavirus disease 2019 (COVID-19) can range from simple tremors and dystonia to features of encephalopathy. Toll-like receptor 7 (TLR7) belongs to a family of innate immune receptors responsible for viral RNA detection (such as SARS-CoV-2) and immune response initiation. TLR7 loss of function variants have been previously reported as genetic risk factors for severe COVID-19 infection in young patients with no comorbidities. In this case, we report a pediatric patient who developed severe long-term neurological deterioration following his COVID-19 infection. Presenting first to the clinic with episodic dystonia and finger spasticity, the patient's condition rapidly deteriorated with a significant drop in the Glasgow Coma Scale (GCS). Despite improvement f

SUBMITTER: Noor Eddin A 

PROVIDER: S-EPMC10716429 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature