Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection.

ABSTRACT: Bacterial infections and the concurrent inflammation have been associated with increased long-term cardiovascular (CV) risk. In patients receiving peritoneal dialysis (PD), bacterial peritonitis is a common occurrence, and each episode further increases late CV mortality risk. However, the underlying mechanism(s) remains to be elucidated before safe and efficient anti-inflammatory interventions can be developed. Damage-Associated Molecular Patterns (DAMPs) have been shown to contribute to the acute inflammatory response to infections, but a potential role for DAMPs in mediating long-term vascular inflammation and CV risk following infection resolution in PD, has not been investigated. We found that bacterial peritonitis in mice that resolved within 24h led to CV disease-promoting systemic

SUBMITTER: Cetin E 

PROVIDER: S-EPMC10716465 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature