Association between urinary sodium and circulating lipid levels: a Mendelian randomization study.

ABSTRACT:

Background

Urinary sodium was indicated to be associated with dyslipidemia, but inconsistent conclusions for this association exist across the present observational studies.

Objectives

This study aimed to evaluate the causal association between urinary sodium and circulating lipid levels [low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol (HDL-C)] through Mendelian randomization.

Methods

Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) with pleiotropy-resistant methods were performed. Data for urinary sodium were obtained from the genome-wide association study (GWAS) from 446,237 European individuals. Data for lipid profiles were extracted from GWAS based on the UK Biobank (fo

SUBMITTER: Yuan C 

PROVIDER: S-EPMC10716694 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature