Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway.

ABSTRACT: Oligodendrocyte precursor cells (OPCs) are present in the adult central nervous system (CNS), and their impaired ability to differentiate into myelinating oligodendrocytes (OLs) can lead to demyelination in patients with multiple sclerosis (MS), accompanied by neurological deficits and cognitive impairment. Exosomes, small vesicles released by cells, are known to facilitate intercellular communication by carrying bioactive molecules. In this study, we utilized exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs-Exos). We performed sequencing and bioinformatics analysis of exosome-treated cells to demonstrate that HUMSCs-Exos can stimulate myelin gene expression in OPCs. Functional investigations revealed that HUMSCs-Exos activate the Pi3k/Akt pathway and regulate the

SUBMITTER: Qin D 

PROVIDER: S-EPMC10716775 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature