Transcriptional Response of Candida albicans to Nanostructured Surfaces Provides Insight into Cellular Rupture and Antifungal Drug Sensitization.

ABSTRACT: The rise in resistance levels against antifungal drugs has necessitated the development of strategies to combat fungal infections. Nanoscale antimicrobial surfaces, found on the cuticles of insects, have recently emerged as intriguing alternative antifungal strategies that function passively via contact and induced cell rupture. Nanostructured surfaces (NSS) offer a potentially transformative antimicrobial approach to reducing microbial biofilm formation. We examined the transcriptional response of Candida albicans, an opportunistic pathogen that is also a commensal dimorphic fungus, to the NSS found in the wings of Neotibicen spp. cicada and found characteristic changes in the expression of C. albicans genes associated with metabolism, biofilm formation, ergosterol bi

SUBMITTER: Chivukula LG 

PROVIDER: S-EPMC10716851 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature