Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells.

ABSTRACT:

Background

The basal ganglia are a complex of interconnected subcortical structures located beneath the mammalian cerebral cortex. The degeneration of dopaminergic neurons in the basal ganglia is the primary pathological feature of Parkinson's disease. Due to a lack of integrated analysis of multiomics datasets across multiple basal ganglia brain regions, very little is known about the regulatory mechanisms of this area.

Findings

We utilized high-throughput transcriptomic and epigenomic analysis to profile over 270,000 single-nucleus cells to create a cellular atlas of the basal ganglia, characterizing the cellular composition of 4 regions of basal ganglia in adult macaque brain, including the striatum, substantia nigra (SN), globus pallidum, and amygdala. We found a distinc

SUBMITTER: Li Z 

PROVIDER: S-EPMC10716911 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature