Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats.

ABSTRACT: Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and

SUBMITTER: Abe C 

PROVIDER: S-EPMC10716925 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature