Genetic association studies in critically ill patients: protocol for a systematic review.

ABSTRACT:

Introduction

Patients in the intensive care unit (ICU) are highly heterogeneous in characteristics, their clinical course, and outcomes. Genetic variability may partly explain the variability and similarity in disease courses observed among critically ill patients and may identify clusters of subgroups. The aim of this study is to conduct a systematic review of all genetic association studies of critically ill patients with their outcomes.

Methods and analysis

This systematic review will be conducted and reported according to the HuGE Review Handbook V1.0. We will search PubMed, Embase, and the Cochrane Library for relevant studies. All types of genetic association studies that included acutely admitted medical and surgical adult ICU patients will be considered for this revi

SUBMITTER: Cox EGM 

PROVIDER: S-EPMC10716946 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature