Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have documented an inverse association of birthweight with myocardial infarction (MI) but a positive association with atrial fibrillation (AF). However, the causality of these associations and the underlying mediating pathways remain unclear. We aimed to investigate the causal effects of birthweight, incorporating both fetal and maternal genetic effects, on MI and AF, and identify potential mediators in their respective pathways.

Methods

We performed Mendelian randomization (MR) analyses using genome-wide association study summary statistics for birthweight (N = 297,356 for own birthweight and 210,248 for offspring birthweight), MI (N_case=61,000, N_control=577,000), AF (N_case=60,620, N_control

SUBMITTER: Kong L 

PROVIDER: S-EPMC10716951 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature