Construction of a risk stratification model integrating ctDNA to predict response and survival in neoadjuvant-treated breast cancer.

ABSTRACT:

Background

The pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) of breast cancer is closely related to a better prognosis. However, there are no reliable indicators to accurately identify which patients will achieve pCR before surgery, and a model for predicting pCR to NAC is required.

Methods

A total of 269 breast cancer patients in Shandong Cancer Hospital and Liaocheng People's Hospital receiving anthracycline and taxane-based NAC were prospectively enrolled. Expression profiling using a 457 cancer-related gene sequencing panel (DNA sequencing) covering genes recurrently mutated in breast cancer was carried out on 243 formalin-fixed paraffin-embedded tumor biopsies samples before NAC from 243 patients. The unique personalized panel of nine individual

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10717175 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature