Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism.

ABSTRACT: Maternal-fetal calcium (Ca²⁺) transport in the placenta plays a critical role in maintaining fetal bone mineralization. Mutations in the gene encoding the transient receptor potential cation channel, subfamily V, member 6 (TRPV6) have been identified as causative mutations of transient neonatal hyperparathyroidism due to insufficient maternal-fetal Ca²⁺ transport in the placenta. In this study, we found two novel mutations in subjects that have transient neonatal hyperparathyroidism. TRPV6 carrying the mutation p.Arg390His that localizes to the outer edge of the first transmembrane domain (S1) showed impaired trafficking to the plasma membrane, whereas TRPV6 having the mutation p.Gly291Ser in the sixth ankyrin repeat (AR) domain had channel properties that were compar

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC10717230 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature