Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis.

ABSTRACT:

Background

EAU is an inflammatory disease usually characterized by autoinflammation and autoimmunity and is aggravated by excessive generation of ROS. Conventional hormone therapy often has more adverse effects. It is urgent to find a therapeutic drug with higher efficiency and fewer adverse effects.

Methods

We developed an Fe-curcumin nanozyme in which natural antioxidants coordinate with Fe³⁺ to form nanoparticles with excellent solubility for directing anti-inflammatory and ROS scavenging effects to treat EAU. Several experiments were used to detect the characteristics of nanozymes. EAU model rats were used to detect the abilities of decreasing autoinflammation and autoimmunity. PBMCs were used to detect the ability to inhibit cell proliferation.

Results

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10717250 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature