The lack of slow force response in failing rat myocardium: role of stretch-induced modulation of Ca-TnC kinetics.

ABSTRACT: The slow force response (SFR) to stretch is an important adaptive mechanism of the heart. The SFR may result in ~ 20-30% extra force but it is substantially attenuated in heart failure. We investigated the relation of SFR magnitude with Ca²⁺ transient decay in healthy (CONT) and monocrotaline-treated rats with heart failure (MCT). Right ventricular trabeculae were stretched from 85 to 95% of optimal length and held stretched for 10 min at 30 °C and 1 Hz. Isometric twitches and Ca²⁺ transients were collected on 2, 4, 6, 8, 10 min after stretch. The changes in peak tension and Ca²⁺ transient decay characteristics during SFR were evaluated as a percentage of the value measured immediately after stretch. The amount of Ca²⁺ utilized by TnC was indirec

SUBMITTER: Lookin O 

PROVIDER: S-EPMC10717443 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature