Self-assembly of cyclic peptide monolayers by hydrophobic supramolecular hinges.

ABSTRACT: Supramolecular polymerisation of two-dimensional (2D) materials requires monomers with non-covalent binding motifs that can control the directionality of both dimensions of growth. A tug of war between these propagation forces can bias polymerisation in either direction, ultimately determining the structure and properties of the final 2D ensemble. Deconvolution of the assembly dynamics of 2D supramolecular systems has been widely overlooked, making monomer design largely empirical. It is thus key to define new design principles for suitable monomers that allow the control of the direction and the dynamics of two-dimensional self-assembled architectures. Here, we investigate the sequential assembly mechanism of new monolayer architectures of cyclic peptide nanotubes by computational simulat

SUBMITTER: Insua I 

PROVIDER: S-EPMC10717465 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature