Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis.

ABSTRACT:

Background

Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure of heparin. Regarding the structural and physiological properties of the negatively charged polymers, hexasulfonated suramin, a centuries-old medicine that is still used for treating African trypanosomiasis and onchocerciasis, is assumed to be a heparin-related analog or heparinoid. This investigation aims to elucidate the influence of suramin on the adipogenesis.

Methods

To assess the influence exerted by suramin on adipogenic differentiation of primary white adipocytes in rats, this exploration was conducted both in vitro a

SUBMITTER: Li H 

PROVIDER: S-EPMC10717495 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature