On-DNA hydroalkylation of N-vinyl heterocycles via photoinduced EDA-complex activation.

ABSTRACT: The emergence of DNA-encoded library (DEL) technology has provided a considerable advantage to the pharmaceutical industry in the pursuit of discovering novel therapeutic candidates for their drug development initiatives. This combinatorial technique not only offers a more economical, spatially efficient, and time-saving alternative to the existing ligand discovery methods, but also enables the exploration of additional chemical space by utilizing novel DNA-compatible synthetic transformations to leverage multifunctional building blocks from readily available substructures. In this report, a decarboxylative-based hydroalkylation of DNA-conjugated N-vinyl heterocycles enabled by single-electron transfer (SET) and subsequent hydrogen atom transfer through electron-donor/electron-accep

SUBMITTER: Sharique M 

PROVIDER: S-EPMC10717525 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature