The mechanism of Sanzi Yangqin decoction for asthma treatment based on network pharmacology and experimental verification.

ABSTRACT:

Background

Asthma is a chronic airway inflammatory disease characterized by airway inflammation, mucus hypersecretion, airway hyper-reactivity. Sanzi Yangqin Decoction (SZYQD) is widely prescribed for asthma treatment. Its anti-asthma activities have been reported in animal model, but the exact mechanism and targets of SZYQD in asthma treatment have not been fully elucidated.

Methods

A network pharmacological approach was used to predict the active components, targets, and signalling pathways of SZYQD in asthma, including potential target prediction, protein‒protein interaction (PPI) network construction and analysis, and Gene Ont (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The active ingredients were identified from the SZYQD, and were molecula

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10717567 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature