Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice.

ABSTRACT: We aimed to identify the neurotransmitters and brain regions involved in exercise efficiency in mice during continuous complicated exercises. Male C57BL/6J mice practiced treadmill running with intermittent obstacles on a treadmill for 8 days. Oxygen uptake (VO₂) during treadmill running was measured as exercise efficiency. After obstacle exercise training, the VO₂ measured during treadmill running with obstacles decreased significantly. Obstacle exercise-induced c-Fos expressions and dopamine turnover (DOPAC/dopamine) in the septum after obstacle exercise training were significantly higher than that before training. The dopamine turnover was correlated with exercise efficiency on the 3rd day after exercise training. Furthermore, the training effect on exercise effici

SUBMITTER: Shiuchi T 

PROVIDER: S-EPMC10717687 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature