Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population.

ABSTRACT: Recent studies on the association between particular single nucleotide polymorphisms of serine-threonine kinase with no lysine (K) 4 gene (WNK4) and essential hypertension have yielded controversial results. Here, frequencies of Ala589Ser polymorphism within exon 8 of the WNK4 gene were assessed among 259 unrelated ethnic Chinese patients with essential hypertension and 235 strictly matched normotensive controls. All subjects were derived from a relatively isolated population identified in the Kerqin desert region in Zhangwu county of Liaoning, northeastern China, which features a dry climate and the people having a high dietary salt intake, in addition to a significantly higher prevalence (approximately 35%) of essential hypertension. Genotypes were verified with polymerase chain reaction

SUBMITTER: Sun ZJ 

PROVIDER: S-EPMC10717746 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature