Umbilical cord mesenchymal stromal cells in serum-free defined medium display an improved safety profile.

ABSTRACT:

Background

Safety evaluations in preclinical studies are needed to confirm before translating a cell-based product into clinical application. We previously developed a serum-free, xeno-free, and chemically defined media (S&XFM-CD) for the derivation of clinical-grade umbilical cord-derived MSCs (UCMSCs), and demonstrated that intraperitoneal administration of UCMSCs in S&XFM-CD (UCMSC^S&XFM-CD) exhibited better therapeutic effects than UCMSCs in serum-containing media (SCM, UCMSC^SCM). However, a comprehensive investigation of the safety of intraperitoneal UCMSC^S&XFM-CD treatment should be performed before clinical applications.

Methods

In this study, the toxicity, immunogenicity and biodistribution of intraperitoneally transplanted UCMSC^S

SUBMITTER: Wu X 

PROVIDER: S-EPMC10717764 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature