Therapeutic effect of adipose-derived mesenchymal stem cells in a porcine model of abdominal sepsis.

ABSTRACT:

Background

The term sepsis refers to a complex and heterogeneous syndrome. Although great progress has been made in improving the diagnosis and treatment of this condition, it continues to have a huge impact on morbidity and mortality worldwide. Mesenchymal stem cells are a population of multipotent cells that have immunomodulatory properties, anti-apoptotic effects, and antimicrobial activity. We studied these capacities in a porcine model of peritoneal sepsis.

Methods

We infused human adipose-derived mesenchymal stem cells (ADSCs) into a porcine model of peritoneal sepsis. Twenty piglets were treated with antibiotics alone (control group) or antibiotics plus peritoneal infusion of ADSCs at a concentration of 2 × 10⁶ cells/kg or 4 × 10⁶ cells/kg (low-

SUBMITTER: Velez-Pinto JF 

PROVIDER: S-EPMC10717819 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature