Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

ABSTRACT:

Objective

To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design.

Methods

Two-sample bi-directional MR analyses were performed using summary-level information on OA traits from UK Biobank and arcOGEN. Sensitivity analyses including MR-Egger, simple median, weighted median, MR pleiotropy residual sum, and outlier approaches were utilized in conjunction with inverse variance weighting (IVW). Gene ontology (GO) enrichment analyses and expression quantitative trait locus (eQTL) colocalization analyses were used to investigate the potential mechanism and shared genes between osteoporosis (OP) and OA.

Results

The IVW method revealed that genetically predicted low femoral neck BMD was si

SUBMITTER: Qu Y 

PROVIDER: S-EPMC10717893 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature